Tesamorelin Peptide Profile

Category: Growth Hormone-Releasing Hormone (GHRH) Analog
Chemical Name: [N-(2-methyl-propanoic acid)-L-tyrosine-L-arginyl]-growth hormone-releasing factor (1-29) amide
Molecular Formula: C211H366N72O67S
Molecular Weight: Approximately 5135 Daltons

Mechanism of Action
Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH). It works by stimulating the pituitary gland to release growth hormone (GH), which in turn increases the production of insulin-like growth factor-1 (IGF-1) in the liver. The elevation of IGF-1 levels promotes anabolic effects, fat metabolism, and improved body composition. Unlike direct GH therapy, Tesamorelin encourages the body’s natural production of GH, reducing the risk of side effects associated with supraphysiological levels of GH.

Benefits

Reduction of Visceral Fat: Tesamorelin is FDA-approved for reducing excess abdominal fat in HIV-associated lipodystrophy. It also shows potential for general visceral fat reduction.
Improved Body Composition: Promotes fat loss while preserving lean muscle mass.
Increased IGF-1 Levels: Enhances IGF-1 production, contributing to muscle growth, tissue repair, and overall anabolic effects.
Metabolic Health: Improves glucose metabolism and insulin sensitivity, beneficial for metabolic disorders.
Cognitive and Neuroprotective Effects: Preliminary studies suggest Tesamorelin may support cognitive function and brain health, potentially delaying neurodegenerative diseases.

Dosage and Administration
Tesamorelin is administered via subcutaneous injection, typically at a dose of 2 mg once daily. It is usually injected into the abdomen, avoiding areas with significant subcutaneous fat.

Side Effects

Injection Site Reactions: Redness, swelling, or irritation at the injection site.
Joint and Muscle Pain: Associated with increased GH activity.
Peripheral Edema: Fluid retention may occur in some individuals.
Insulin Resistance: Potential risk in individuals predisposed to diabetes.
Carpal Tunnel Syndrome: Rarely observed with long-term use.

Legal Status
Tesamorelin is FDA-approved for specific medical conditions, such as HIV-associated lipodystrophy. However, its use for non-medical or off-label purposes is strictly regulated.

Conclusion
Tesamorelin is a powerful GHRH analog with proven benefits in reducing visceral fat, improving body composition, and enhancing metabolic health. Its ability to stimulate natural GH production makes it a safer alternative to direct GH therapy, though it should only be used under medical supervision.