Semax Peptide Profile
Category: Neuroprotective and Nootropic Peptide
Chemical Name: Methionyl-Glutamyl-Histidyl-Phenylalanyl-Prolyl-Glycyl-Proline
Molecular Formula: C37H51N9O10S
Molecular Weight: Approximately 813 Daltons
Mechanism of Action
Semax is a synthetic peptide derived from adrenocorticotropic hormone (ACTH) fragments, specifically designed for its neuroprotective and cognitive-enhancing properties. It acts on the central nervous system (CNS) by modulating the expression of brain-derived neurotrophic factor (BDNF) and other neurotrophic factors. Semax enhances synaptic plasticity, regulates neurotransmitter levels (particularly dopamine and serotonin), and protects neurons from oxidative stress, ischemia, and inflammation.
Benefits
- Cognitive Enhancement
- Improves focus, memory, and learning by supporting synaptic plasticity.
- Neuroprotection
- Reduces neuronal damage caused by oxidative stress, ischemia, and neuroinflammation.
- Mood Regulation
- Modulates dopamine and serotonin levels, reducing anxiety and depression symptoms.
- Stroke Recovery
- Enhances post-stroke rehabilitation by promoting neurogenesis and reducing brain damage.
- Improved Circulation
- Enhances blood flow to the brain, improving oxygenation and nutrient delivery.
- Stress Adaptation
- Helps the body adapt to chronic stress by regulating CNS responses.
Dosage and Administration
Semax is typically administered intranasally for rapid absorption into the CNS. Dosages vary based on therapeutic goals:
- Cognitive Enhancement: 200-500 mcg per day.
- Post-Stroke Recovery: Higher doses may be prescribed under medical supervision.
Side Effects
- Mild Irritation: Nasal application may cause temporary discomfort.
- Transient Headache: Rarely reported, often mild.
- Overstimulation: Higher doses may lead to restlessness or difficulty sleeping.
Legal Status
Semax is approved for medical use in certain countries (e.g., Russia) for neurological disorders. It is not FDA-approved in the United States and is typically available as a research chemical or nootropic supplement.
Conclusion
Semax is a versatile peptide offering neuroprotective and nootropic benefits. Its ability to enhance cognitive function, regulate mood, and support stroke recovery makes it a valuable tool in neurological health and brain optimization.
Semax Peptide Profile
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THIS SEMAX PEPTIDE INFORMATION IS FOR BOTH ADULT MALES AND ADULT FEMALES.
| Peptide Profile: Semax | Category | Beginner | Intermediate | Advanced | Frequency | Duration | Notes |
|---|---|---|---|---|---|---|---|
| Adult Males | Cognitive enhancement / focus | 300–600 mcg intranasal per day (1–2 sprays per nostril) | 600–900 mcg total daily (split AM/PM) | Up to 1,200 mcg daily (doctor supervised) | 1–2× daily | 10–20 days, then off-cycle 1–2 weeks | Avoid dosing close to bedtime; may cause alertness or insomnia. |
| Adult Females | Cognitive enhancement / neuroprotection | 200–400 mcg intranasal per day (1 spray per nostril) | 400–800 mcg total daily | Up to 1,000 mcg daily (doctor supervised) | 1–2× daily | 10–20 days, then off-cycle 1–2 weeks | Start low to assess sensitivity; avoid nasal irritation by alternating nostrils. |
| Therapeutic Context | – | Studied for stress resistance, memory, and neuroprotection | May improve mood, focus, and recovery after fatigue | Investigational in brain injury recovery | Daily or as prescribed | 2–4 week cycles | Derived from ACTH fragment; non-stimulant, non-sedative. |
| Administration | Route | Intranasal spray | – | – | AM or midday | – | Avoid touching dropper to skin or nostrils to prevent contamination. |
| Stacking Options | Combine with Selank for anti-anxiety benefits | – | – | – | – | – | Not to be combined with strong stimulants or other neuropeptides without guidance. |
| Storage | Refrigerate 2–8 °C (36–46 °F) | Protect from light | Do not freeze | Use within 30 days of opening | – | – | Keep capped tightly and upright. |
⚠️ Warning: This chart is for educational purposes only and is not professional medical advice. Always consult a qualified healthcare provider before using Semax or any peptide therapy.
