Below is a 200‑word summary of a Semax peptide dosing protocol in APA format (with a dosing chart). Note: Semax is not FDA‑approved in many countries, and clinical dosing guidance is limited; widely circulated protocols are based on Russian clinical use and intraclinical/experimental recommendations, not universally accepted medical standards.
Semax Peptide Dosing Protocol
Semax is a synthetic regulatory peptide (ACTH analog) used in Russia and Eastern Europe for neuroprotection and cognitive enhancement (intranasal or injectable), influencing brain‑derived neurotrophic factor (BDNF) and cognitive functions (Wikipedia, 2025). Clinical and experimental protocols recommend intranasal dosing of 250–1,000 mcg per administration, repeated 1–3 times daily depending on condition and response (RecessRx, 2025; VOAFIT, 2025). Typical nootropic use starts at lower doses (e.g., 250–400 mcg) and increases based on efficacy and tolerance.
For more intensive therapeutic goals (e.g., stroke recovery in research contexts), intranasal protocols use higher cumulative daily doses (up to several thousand mcg) administered over short cycles (e.g., 10–14 days) with rest periods (Peptides.org, 2024). Subcutaneous injectable protocols exist in off‑label peptide circles, often starting around 300 mcg daily, with gradual titration to 600–800 mcg over weeks (PeptideDosages.com, 2025). These regimens typically run for 4–8 weeks, sometimes extended with breaks to prevent adaptation.
Individual response and safety must be monitored; mild side effects include nasal irritation or headache, and medical supervision is advised given the experimental nature of off‑label use (Synapse Patsnap, 2024; RecessRx, 2025).
Semax Dosing Chart (General Guidelines)
| Route | Dose per Administration | Frequency | Cycle/Duration |
|---|---|---|---|
| Intranasal (nootropic) | 250–400 mcg | 1–3× daily | 2–4 weeks |
| Intranasal (higher/clinical) | 600–2,000 mcg | 2–4× daily | 10–14 days with rest |
| Injectable (subcutaneous) | 300–800 mcg | Daily | 4–8 weeks |
| Injectable (high/experimental) | Up to 1,000 mcg | Daily or 2–3× weekly† | 8–12 weeks† |
† Protocols vary widely; these are based on peptide therapy practice, not official clinical standards.
References
RecessRx. (2025). Semax dosing and effects. Retrieved from search results. (Recess Rx)
VOAFIT. (2025). Semax peptide overview and dosing. Retrieved from search results. (Voafit)
Peptides.org. (2024). Semax dosage calculator and protocols. Retrieved from search results. (Peptides.org)
PeptideDosages.com. (2025). Semax 10 mg vial dosage protocol. Retrieved from search results. (peptidedosages.com)
Synapse Patsnap. (2024). Semax uses and dosing considerations. Retrieved from search results. (Synapse)
Wikipedia. (2025). Semax. Retrieved from search results. (en.wikipedia.org)
