IGF‑DES (also known as des(1‑3)IGF‑1) is a truncated, recombinant analogue of Insulin‑Like Growth Factor‑1 (IGF‑1) from which the first three amino acids at the N‑terminus are removed, resulting in a 67‑amino‑acid peptide with significantly reduced binding to IGF‑binding proteins and enhanced bioactivity compared to native IGF‑1. This structural modification increases its potency (≈10×) and receptor availability, leading to more pronounced anabolic effects on muscle growth, tissue repair, and localized hypertrophy in research settings. (Wikipedia)
IGF‑DES is predominantly discussed in experimental, athletic, and bodybuilding contexts for its potential to stimulate muscle protein synthesis, improve recovery, support injury repair, and aid in targeted development of lagging muscle groups. It may also influence nutrient uptake (e.g., glucose, amino acids) into muscle cells, further enhancing anabolic signaling. (Swolverine)
There are no approved clinical dosing protocols or human trials; most available “dosage” suggestions are anecdotal or based on extrapolation from IGF‑1 research, and IGF‑DES analogues are prohibited in sport by anti‑doping agencies. (researchgate.net)
IGF‑DES Dosing Chart (Anecdotal / Research‑Oriented)
| Parameter | Suggested Range | Notes |
| Daily Dose | ~50–100 mcg/day | Administered subcutaneously; theoretical only, no clinical approval (peptides.org)
| Frequency | 1–2 injections/day | Often timed around exercise for potential anabolic window (peptides.org)
| Timing | Pre‑ and/or post‑workout | May enhance nutrient uptake and recovery (peptides.org)
| Duration | ~4–6 weeks | Typical anecdotal cycle with equivalent off‑period (peptides.org)
References (APA):
Bailes, J., & Soloviev, M. (2021). Insulin‑Like Growth Factor‑1 (IGF‑1) and Its Monitoring in Medical Diagnostic and in Sports. Biomolecules, 11(2), 217. (MDPI)
Des(1‑3)IGF‑1. (n.d.). Wikipedia. (Wikipedia)
IGF‑1 DES Guide: Benefits, Dosage, Stacking, and Side … (2025, June 10). Swolverine. (Swolverine)
IGF‑1 DES Dosage Calculator and Chart | A‑Z Guide. (n.d.). Peptides.org. (peptides.org)
