MOTS‑c Dosing Protocol Summary
MOTS‑c (mitochondrial open reading frame of the 12S rRNA‑c) is a 16‑amino‑acid mitochondrial‑derived peptide that regulates metabolic homeostasis, insulin sensitivity, and skeletal muscle function and is upregulated by exercise in humans (Reynolds et al., 2021; Wikipedia, 2025). Research shows it can improve metabolic parameters such as glucose regulation and physical performance in animal models by activating AMPK and related pathways (Reynolds et al., 2021; Lee et al., 2015). MOTS‑c is still experimental, not FDA‑approved, and dosing in humans remains investigational (USADA, 2025; HubMedEd, 2025). Proposed dosing protocols are based on peptide use guides and pilot research exploration. A common approach involves subcutaneous administration, titrating dose over weeks to improve tolerance (PeptideDosages.com, 2025). Research dosing examples range widely in animal studies (e.g., 0.5–15 mg/kg) with varying durations (Pham et al., 2025). Clinicians and research guides suggest daily or multiple‑times‑weekly injections over 8–12 weeks with follow‑up periods, although optimal regimens are unvalidated in controlled human trials (PeptideDosages.com, 2025; AmericanMedicalWellness, 2025). Safety, long‑term effects, and efficacy in humans require further clinical study.
MOTS‑c Dosing Chart (Investigational/Research Context)
| Week(s) | Suggested Dose (subcutaneous) | Frequency | Notes |
|---|---|---|---|
| 1–2 | 200 mcg | Daily | Start low for tolerance monitoring (PeptideDosages.com, 2025) |
| 3–4 | 400 mcg | Daily | Titrate upward if tolerated |
| 5–6 | 600 mcg | Daily | Ongoing assessment |
| 7–8 | 800 mcg | Daily | Preclinical extrapolation |
| 9–12+ | up to 1000 mcg (1.0 mg) | Daily | Maximum suggested in protocols not clinically validated |
References (APA Format)
AmericanMedicalWellness. (2025). MOTS‑c: How to take it and peptide benefits.
HubMedEd. (2025). What is MOTS‑c peptide?
PeptideDosages.com. (2025). MOTS‑C (10mg vial) dosage protocol.
Reynolds, J. C., et al. (2021). MOTS‑c: Exercise‑induced mitochondrial‑encoded peptide. Nature Communications.
Wikipedia. (2025). MOTS‑c. Wikipedia.
USADA. (2025). What is the MOTS‑c peptide?
⚠️ Disclaimer: This summary is for informational purposes and reflects investigational dosing protocols, not medical advice. MOTS‑c is not FDA‑approved for therapeutic use in humans, and dosing standards are not established in clinical settings. Always consult qualified healthcare professionals and relevant primary research before considering any peptide interventions. (PMC)
