Lysine‑Proline‑Valine (KPV) Tripeptide Profile and Dosing Protocol
KPV is a naturally occurring tripeptide composed of the amino acids lysine, proline, and valine, derived from the C‑terminal end of the alpha‑melanocyte‑stimulating hormone (α‑MSH) sequence (lysine‑proline‑valine) (Xiao et al., 2017). This small peptide retains potent anti‑inflammatory, immune‑modulating, and antimicrobial properties without significant hormonal activity, making it of interest in therapeutic and cosmetic applications (Revolution Health, 2025; Text2MD, 2025). Research suggests KPV can attenuate inflammatory pathways, potentially supporting conditions involving gut inflammation, skin repair, and immune balance (Innerbody Research, 2025). Lysine, one component of KPV, is essential for collagen synthesis and immune function, underscoring its role in tissue repair (MassiveBio, 2025). Proline, another constituent, contributes to collagen structure and connective tissue integrity (WebMD, 2025). Valine, an essential branched‑chain amino acid, supports protein synthesis and metabolic functions (Wikipedia, 2025). While clinical human dosing protocols remain limited, emerging guidance from peptide therapy practitioners suggests both oral and subcutaneous administration approaches. Standardized dosing often ranges from 200–400 micrograms daily for subcutaneous KPV and 250 micrograms twice daily orally, though adjustment by healthcare providers is recommended (Peptides.org, 2025).
KPV Dosing Chart (Illustrative)
| Administration Method | Suggested Dose | Frequency |
|---|---|---|
| Subcutaneous injection | 200–400 mcg | Once daily |
| Oral administration | 250 mcg | Twice daily |
References
Innerbody Research. (2025). KPV peptide: Benefits, safety & buying advice. Retrieved from https://www.innerbody.com/kpv-peptide (Innerbody)
MassiveBio. (2025). L‑Lysine: Collagen production and immune support. Retrieved from https://massivebio.com/l-lysine-collagen-production-and-immune-support-bio/ (Massive Bio)
Peptides.org. (2025). KPV dosage calculator and chart. Retrieved from https://www.peptides.org/kpv-dosage-calculator/ (Peptides.org)
Revolution Health. (2025). KPV peptide: A breakthrough for inflammation, immunity. Retrieved from https://revolutionhealth.org/blogs/news/peptide-therapy-kpv (Revolution Health & Wellness)
Text2MD. (2025). Peptide therapy: KPV benefits and uses. Retrieved from https://text2md.com/blog/peptide-therapy/ (text2md.com)
WebMD. (2025). Proline — Uses, side effects, and more. Retrieved from https://www.webmd.com/vitamins/ai/ingredientmono-1620/proline (WebMD)
Wikipedia contributors. (2025). Valine. In Wikipedia. Retrieved from https://en.wikipedia.org/wiki/Valine (Wikipedia)
Xiao, B., et al. (2017). Orally targeted delivery of tripeptide KPV via hyaluronic acid. PMC. (pmc.ncbi.nlm.nih.gov)
Note: This summary reflects research findings and proposed dosing guidelines from publicly available peptide therapy resources and not standardized clinical recommendations. Always consult a licensed medical professional before beginning any peptide protocol.
