Glutathione is a naturally occurring tripeptide composed of glutamate, cysteine, and glycine that functions as a critical intracellular antioxidant, detoxifier, and regulator of redox homeostasis in the body (GSH) (Wikipedia). Clinical dosing protocols vary depending on the route of administration and therapeutic goals. For intravenous (IV) use, common regimens in research and compounding guidelines include 600–1,200 mg once or twice weekly for general antioxidant support, 1,000–2,000 mg 1–2 times weekly for liver detoxification support, and 1,200–2,400 mg twice weekly for off‑label skin brightening protocols under medical supervision (membership.diversifyrx.com). Intramuscular (IM) dosing typically ranges from 200–600 mg per injection, 1–3 times weekly, with maximum single doses around 1,200 mg split across sites (membership.diversifyrx.com). Oral dosing is less standardized due to low bioavailability, but supplemental doses of 500–2,000 mg daily are often discussed for general antioxidant support or specific indications, with higher doses sometimes used clinically for conditions such as chemotherapy support under professional guidance (Vinmec International Hospital). Safety profiles vary by route; IV administration should occur only under qualified supervision due to potential serious adverse events reported in some studies (PMC).
Glutathione Dosing Chart
| Route | Indication | Dose | Frequency |
|---|---|---|---|
| IV | Antioxidant support | 600–1,200 mg | 1–2×/week |
| IV | Liver detox | 1,000–2,000 mg | 1–2×/week |
| IV | Skin brightening (off‑label) | 1,200–2,400 mg | 1–2×/week |
| IM | General wellness | 200–600 mg | 1–3×/week |
| Oral | General support | 500–2,000 mg | Daily |
