GHK‑Cu (glycyl‑histidyl‑lysine copper) is a naturally occurring tripeptide that binds copper and supports tissue regeneration, collagen and elastin synthesis, wound healing, and skin/hair health by modulating cellular pathways and promoting antioxidant and anti‑inflammatory effects. It is widely used in cosmetic and therapeutic contexts, with topical concentrations typically 1–3% for skin benefits, and injectable protocols often applied subcutaneously for deeper regenerative effects. GHK‑Cu levels decline with age, correlating with reduced regenerative capacity. Its purported benefits include improved skin firmness, reduced wrinkles, enhanced wound repair, and hair growth stimulation, though professional supervision is recommended for therapeutic use. Safety data suggest low toxicity, but individualized dosing and monitoring are important, especially with injectable forms. Topical products usually apply once or twice daily, while injection protocols range from 1–2 mg per session several times per week over an 8–12‑week cycle. GHK‑Cu’s clinical use should be tailored to individual goals and overseen by a qualified healthcare provider. Injectable reconstitution with sterile water and proper refrigerated storage after reconstitution are standard practices. Consult a clinician to determine optimal dosing for specific conditions. (peptidedosages.com)

GHK‑Cu Dosing Chart (General Guidelines)
| Form | Dose | Frequency | Duration | Notes |
| Topical serum | 1–3% | 1–2× daily | Ongoing | Apply to clean skin | (ipharmapharmacy.com)
| Injectable (subcutaneous) | 1 mg | 5×/week | Weeks 1–4 | Conservative start | (peptidedosages.com)
| Injectable (subcutaneous) | 1.5 mg | 5×/week | Weeks 5–8 | Titrate upward | (peptidedosages.com)
| Injectable (subcutaneous) | 2 mg | 3–5×/week | Weeks 9–12+ | Maintenance/advanced | (peptidedosages.com)

References (APA):
Pickart, L., et al. (2015). GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. BioMed Research International. (PMC)
GHK‑Cu Peptide Dosage Protocol. (n.d.). PeptideDosages.com. (peptidedosages.com)
GHK‑Cu Peptide | Innerbody. (2025). Innerbody. (Innerbody)
GHK‑Cu Dosing Guide. (2025). Alpha Bio Med. (45330025.fs1.hubspotusercontent-na1.net)